Chlamydia, Inflammation, and Atherogenesis
نویسندگان
چکیده
منابع مشابه
Chlamydia, inflammation, and atherogenesis.
Atherosclerotic lesions are initiated and progress largely as a result of a chronic, fibroproliferative, inflammatory response. This review discusses how Chlamydia pneumoniae could conceivably contribute to this chronic inflammatory response and reports on recent in vivo and in vitro studies. In vivo studies in mice demonstrate that C. pneumoniae infection is disseminated to the artery wall fol...
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Atherosclerotic vascular disease remains the main cause of morbidity and mortality worldwide, especially in industrialized countries. Impressive and permanently growing research of the recent past has partially changed and further extended our understanding about this broad disease. So far, atherosclerosis results not solely from imbalanced lipid metabolism with lipoprotein retention in the art...
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Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothel...
متن کاملPlatelets in Inflammation and Atherogenesis
Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in developme...
متن کاملGinkgolide B Reduces Atherogenesis and Vascular Inflammation in ApoE−/− Mice
AIMS To investigate whether ginkgolide B (a platelet-activating factor inhibitor) affects vascular inflammation in atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice. METHODS AND RESULTS Human platelets were used to evaluate the effects of ginkgolide B on platelet aggregation and signal transduction. Ginkgolide B attenuated platelet aggregation and inhibited phosphatidylinosito...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2000
ISSN: 0022-1899,1537-6613
DOI: 10.1086/315618